Health-care ETFs
IBB vs XBI.
iShares Biotechnology ETF (NYSE Biotechnology) against SPDR S&P Biotech ETF (S&P Biotechnology Select Industry) — fees, long-horizon total returns, holdings overlap, and sector tilt, side by side.
Performance · total returndaily bars · as of 2026-07-16
| IBB | XBI | SPREAD | |
|---|---|---|---|
| YTD (cumulative) | — | +24.8% | — |
| 1Y CAGR | — | +73.9% | — |
| 3Y CAGR | — | +21.9% | — |
| 5Y CAGR | — | +3.97% | — |
| 10Y CAGR | — | +10.4% | — |
| Since inception CAGR | — | +11.8% | — |
Total return: dividend- and split-adjusted daily closes (distributions reinvested). Spread is IBB minus XBI. XBI since-inception measured from first available bar February 6, 2006. Since-inception spans differ — compare that row with care.
Fund facts
| IBB | XBI | |
|---|---|---|
| Name | iShares Biotechnology ETF | State Street SPDR S&P Biotech ETF |
| Category | Health | Health |
| Style | Passive | Passive |
| Expense ratio | 0.45% | 0.35% |
| Assets (AUM) | $9.1B | $10.7B |
| Dividend yield | 0.22% | 0.36% |
| Avg volume (3-mo) | 1.6M | 8.9M |
| Inception | February 5, 2001 | January 31, 2006 |
| Benchmark proxy | S&P 500 | S&P 500 |
XBI costs 0.1 pp less per year — about $10.00 per $10,000 invested.
Holdings overlaptop-25 holdings · coverage IBB 44.7% · XBI 13.3%
1.2%of portfolio weight overlaps1 shared of top 10
| Shared holding | IBB | XBI | MIN |
|---|---|---|---|
| RVMDRevolution Medicines Inc Ordinary Shares | 2.78% | 1.20% | 1.20% |
Sum of min(weight in each fund) across shared tickers — the standard fund-overlap measure. Computed on the top 25 holdings each fund reports, so it is a lower bound; the coverage figures show how much of each fund those top holdings represent.
Sector tilt IBB XBI
Healthcare100.0% / 99.5%+0.5pp
Financial Services— / 0.5%
More health-care etfs
ALAN GLOBAL INTELLIGENCE · alanglobalintelligence.comdaily bars as of 2026-07-16 · fund facts · issuer-verified · holdings · fund data provider
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For information and research only. Not investment advice. ALAN does not place trades or execute orders. Figures come from the sources shown and can lag the market; verify independently before making decisions. Past performance is not predictive of future results.